But this is just the tip of the ice berg so many articles & studies are coming out challenging the safety of Titanium Dioxide in our food supply & personal care products.

Lomon, one of the leading titanium dioxide manufacturers in China, produces the R996 grade titanium dioxide with purity levels exceeding 99%. This high purity ensures that the pigment provides excellent hiding power and color retention in paints, making it a popular choice for the paint industry.

Dawn Polymer Material, a brother company of Dawn Titanium, has successfully applied for an Initial Public Offerings (IPO), which has started rumours about Dawn Titanium is also about to apply for the IPO.

This constant high rate of ROS production leads rapidly to extreme macromolecular oxidation, here it is observed in the AOPP and MDA detected after 3 h in samples treated with bare P25TiO₂NPs (Fig. 6, Fig. 7). Macromolecular oxidation includes, among others, both protein and lipid oxidation. The ROS causes protein oxidation by direct reaction or indirect reactions with secondary by-products of oxidative stress. Protein fragmentation or cross-linkages could be produced after the oxidation of amino acid side chains and protein backbones. These and later dityrosine-containing protein products formed during excessive production of oxidants are known as advanced oxidation protein products (AOPP). They absorb at 340 nm and are used to estimate the damage to structural cell amino acids. Lipid oxidation is detected by the conjugation of oxidized polyunsaturated lipids with thiobarbituric acid, forming a molecule that absorbs light at 532 nm. Polyunsaturated lipids are oxidized as a result of a free-radical-mediated chain of reactions. The most exposed targets are usually membrane lipids. The macromolecular damage could represent a deadly danger if it is too extensive, and this might be the case. Moreover, it could be observed that cellular damage continues further and becomes irrevocable after 6 h and MDA could not be detected. This may be due to the fact that the lipids were completely degraded and cells were no longer viable. Lipids from the cell membrane are the most prone to oxidation. In fact, lipid peroxidation biomarkers are used to screen the oxidative body balance [51]. At the same time, AOPP values are up to 30 times higher for bare nanoparticles in comparison to the functionalized ones.

TiO₂ NPs appeared to be more toxic to nematode Caenorhabditis elegans than submicron-sized TiO_2.  At a concentration of 1 mg/l, 7 nm particles affected its fertility and survival rate and were more toxic than 20 nm anatase particles. Similarly, Hu et al. showed that rutile particles (10–20 nm), at concentrations above 1 g/kg soil, can be bio-accumulated in earthworms, where they induce oxidative stress, inhibit the activity of cellulase and induce DNA and mitochondrial damage.

In addition to quality, CAS 13463-67-7 also places a strong emphasis on sustainability. The factory is dedicated to reducing its environmental impact by implementing eco-friendly practices and technologies. From waste reduction to energy efficiency, CAS 13463-67-7 is constantly looking for ways to improve its sustainability and contribute to a greener future.